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SB-399885 hydrochloride

CAS No. 402713-81-9

SB-399885 hydrochloride ( SB399885 )

Catalog No. M14379 CAS No. 402713-81-9

SB-399885 is a potent, selective, brain penetrant 5-HT6 receptor antagonist.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    SB-399885 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    SB-399885 is a potent, selective, brain penetrant 5-HT6 receptor antagonist.
  • Description
    SB-399885 is a potent, selective, brain penetrant 5-HT6 receptor antagonist with pKi of 9.11 and 9.02 for human recombinant and native 5-HT6 receptors; SB-399885 is a potent competitive antagonist (pA(2)=7.85), displays over 200-fold selectivity over other receptors; significantly increases extracellular acetylcholine levels in rat medial prefrontal cortex, exhibits cognitive enhancing properties in recognition models; also is an inhibitor of HCV entry in liver-derived cell lines as well as primary hepatocytes, modulates localization of the coreceptor tight junction protein claudin-1 (CLDN1) in a 5-HT6-independent manner, induces intracellular accumulation of CLDN1.
  • Synonyms
    SB399885
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    402713-81-9
  • Formula Weight
    482.80
  • Molecular Formula
    C18H22Cl3N3O4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 125 mg/mL 258.90 mM
  • SMILES
    COC1=C(C=C(C=C1)S(=O)(=O)NC2=C(C(=CC(=C2)Cl)Cl)OC)N3CCNCC3.Cl
  • Chemical Name
    N-(3,5-dichloro-2-methoxyphenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wesoowska A, et al. Eur J Pharmacol. 2008 Mar 17;582(1-3):88-93.
2. Riva L, et al. J Virol. 2018 Apr 27;92(10). pii: e01982-17.
3. Hirst WD, et al. Eur J Pharmacol. 2006 Dec 28;553(1-3):109-19.
4. Wesoowska A, et al. Neuropharmacology. 2007 Apr;52(5):1274-83.
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